Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting
نویسندگان
چکیده
منابع مشابه
HIV-1 Nef and host cell protein kinases.
Nef is a 27-34 kD myristoylated protein unique to primate lentiviruses. A functional Nef gene is important for development of high viremia and simian AIDS in SIV infected rhesus macaques. Notably, animals infected with Nef-deleted attenuated viruses are resistant to subsequent challenge with pathogenic wild-type viruses. A critical role for Nef in development of AIDS in humans has been suggeste...
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ژورنال
عنوان ژورنال: Virology
سال: 2008
ISSN: 0042-6822
DOI: 10.1016/j.virol.2007.08.015